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TOP imaging equipment - Why buy it if you can hire it?

1. Mesoscopic Imaging 'visualization of nano- and microstructures in materials and cell systems'

  • Sample preparation: Preparation of semithin and ultrathin sections sections and smooth surfaces of biological and industrial samples.
  • (Fluorescence) light microscopy: For brightfield and fluorescence imaging, live cell imaging and colocalization studies e.g. dynamic vesicle movements, fluorescence images of sub-cellular structures, materials and catalysis interactions at surfaces.
  • Tomography in 3D: Micro-CT is x-ray imaging in 3D, by the same method used in hospital CT (or "CAT") scans, but on a small scale with massively increased resolution. It really represents 3D microscopy, where very fine scale internal structure of objects is imaged non-destructively. No sample preparation, no staining, no thin slicing - a single scan will image your sample's complete internal 3D structure at high resolution, plus you get your intact sample back at the end.
  • Electron Microscopy (SEM and TEM): Integrated (fluorescence) light and TEM, including tomography on conventional and cryosections. Examine how materials are interconnected and which properties are important by imaging materials in their natural state and experimenting with additional stages for researching physical phenomena.
  • X-Ray Scattering (SAXS and WAXS): Fast crystalline phase analysis to analyse poly-crystalline materials. Analysis of complex morphology elucidation. Also study of properties – such as overall morphology, crystallinity and crystal type, defects and phase composition – and thin film specimens in bulk and under environmental conditions.

2. Molecular Imaging 'identification of complex chemical structures'

  • Nuclear Magnetic Resonance Spectroscopy (NMR): For characterization of complex polymer samples and structure elucidation of small compounds and protein binding studies.
  • Advanced Mass Spectrometry (GC-MS): For routine laboratories working on environmental, chemical and food safety applications, e.g. biological volatiles in breath. High resolution/accurate mass with 2D separation for identification, quantification and speciation in very complex samples.
  • Advanced Mass Spectrometry (LC-MS): Broad screening capabilities for drug metabolism, proteomics, lipidomics, environmental analysis, food safety, toxicology and clinical research applications. Also high resolution for complex polymer analysis, identification, quantification, branching and isomeric separation even with a solid inlet probe.
  • Advanced Mass Spectrometry (MALDI): For identification of chemical composition (monomeric units and end-groups), branching and chemical topology in the field of polymer analysis. Also for determining the spatial molecular distribution in biological surfaces and studying molecular processes, such as ingrowth of a tumor in surrounding tissue, arterial plaque formation, bone fracture healing and tissue regeneration.
  • Raman spectroscopy is a vibrational spectroscopic technique, wheareas the characteristic fingerprinting pattern in a Raman spectrum makes it possible to identify substances including polymorphs and evaluate local crystallinity, orientation and stress.